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Japanese knotweed extract is a nutritional supplement made from the Japanese knotweed plant, a perennial species native to East Asia. This plant, which is also referred to as Polygonum cuspidatum, Reynoutria japonica, and Fallopia japonica, has spread over the world and is now considered an invasive species in North America, Europe, and Canada. It is distinguished by its bamboo-like stems and quick growth, which can reach heights of up to 15 feet. The plant is known to be a difficult invasive species because to its aggressive behaviour and large root system.

Japanese knotweed Extract tree

Japanese knotweed extract has garnered attention due to its possible health advantages and is frequently used as a dietary supplement. It may contain bioactive chemicals like resveratrol. Although studies on its effectiveness are still underway, some claim the extract may have anti-inflammatory and antioxidant qualities. People who are thinking about using it in dietary supplements, however, should be cautious, get medical advice if necessary, and base their decision on scientific data when determining whether it is appropriate for a given health-related usage.


Scientific research has looked at the many health benefits that Japanese knotweed extract, which is made from a resveratrol-rich plant, is said to provide. Here are a few of these benefits:

  • Rich in Antioxidants: The main ingredient in Japanese knotweed extract, resveratrol, is well known for having potent antioxidant qualities. Free radicals are very reactive chemicals that can harm cells and cause a variety of health disorders. It is known to counteract oxidative stress by neutralising these molecules. The possibility for resveratrol to lessen oxidative damage has been investigated in numerous studies. In fact, a 2019 review in the journal “Molecules” emphasised resveratrol’s antioxidant capability and its possible significance in reducing disorders associated with oxidative stress.
  • Cardiovascular Support: According to research, Japanese knotweed extract may have major cardiovascular advantages because of its high resveratrol concentration. It is thought that resveratrol contributes to blood vessel health maintenance, which enhances circulation. A 2011 study that appeared in the “American Journal of Clinical Nutrition” discovered that supplementing with resveratrol enhanced flow-mediated dilation, a blood vessel function indicator, in men who were obese. Additionally, it might aid in controlling cholesterol and blood pressure. Together, these cardiovascular benefits can lower the chance of developing heart disease. Resveratrol’s effect on cardiovascular risk variables was examined in a meta-analysis that was published in “Nutrition, Metabolism & Cardiovascular Diseases” in 2020. The results indicated that resveratrol had a favourable effect on lipid profiles and blood pressure.
  • Anti Inflammatory: Chronic inflammation is linked to a wide range of health problems, from arthritis to neurological illnesses. Resveratrol and other bioactive components found in Japanese knotweed extract have shown promise as anti-inflammatory agents. In 2016, a study that was published in the “Journal of Medicinal Food” examined the anti-inflammatory properties of resveratrol and discovered that it inhibited the synthesis of chemicals that promote inflammation. This anti-inflammatory effect could be relevant to diseases in which inflammation is a major contributing factor.
benefits of Japanese Knotweed Extract: Anti inflammatory

Even though these studies suggest that resveratrol and Japanese knotweed extract may have health benefits, it’s important to remember that further study is required to validate and fully comprehend these effects in humans. Moreover, anyone thinking about adding Japanese knotweed extract to their regimen should consult a doctor, especially if they are also on other medications, to make sure the two are compatible and to figure out the right dosage for their individual circumstances.


The bioactive chemicals in Japanese knotweed extract, particularly resveratrol, are what cause the plant’s benefits on humans when ingested. As a potent antioxidant, resveratrol is essential for lowering oxidative stress and free radical damage. The ageing and destruction of cells, as well as the emergence of numerous chronic illnesses, are linked to this oxidative stress. Resveratrol aids in tissue and cell protection by scavenging free radicals, which may lower the chance of diseases like cancer and heart disease. Its antioxidant qualities lessen the negative consequences of oxidative damage, promoting general health and wellbeing.

The effects of Japanese knotweed extract also reach the cardiovascular system. It is thought that resveratrol strengthens blood vessels, which enhances circulation and may reduce the incidence of heart-related problems. It might possibly have a part in controlling cholesterol and blood pressure. Resveratrol and the extract as a whole improve blood vessel function and lower inflammation, which benefits cardiovascular health. It’s crucial to remember that each person may react differently, and the precise mechanisms of action are still being studied. As a result, further research is necessary to completely comprehend the full range of impacts that the compound has on the human body.


The right amount of Japanese knotweed extract to take depends on a person’s unique circumstances and health goals. The best dosage is still being studied, so it’s important to proceed with caution and seek medical advice if necessary. A major ingredient in Japanese knotweed extract, resveratrol, has been the subject of numerous research looking at possible health benefits at various dosages. Depending on the particular medical condition being studied, dosages ranging from 100 milligrams to 1,500 milligrams per day have been utilised in certain studies. For example, a 2017 randomised, double-blind study that was published in “Nutrients” examined the effects of 75 milligrams of resveratrol per day on cognitive function in older persons.

It’s crucial to emphasise that different people may respond differently to resveratrol or Japanese knotweed extract, and that individual differences may also exist in the best and safest dosage. In addition, the right dosage may vary depending on your age, general health, and any other medications you are taking. Therefore, before adding Japanese knotweed extract to your diet, it is strongly advised that you speak with a healthcare professional. This minimises any possible hazards or interactions and guarantees that the supplement is used safely and efficiently.


Japanese Knotweed Extract is also available as:

  • Trans Resveratrol 20% (Polygonum cuspidatum)
  • Trans Resveratrol 25% (Polygonum cuspidatum)
  • Trans Resveratrol 5% (Polygonum cuspidatum)
  • Trans Resveratrol 50% (Polygonum cuspidatum)
  • Trans Resveratrol 8% (Giant Knotweed) (Fallopia sachalinensis)
  • Trans Resveratrol 95% (Polygonum cuspidatum)
  • Trans Resveratrol 98% (Polygonum cuspidatum)

Japanese Knotweed Extract is commonly available in:

  • Japanese Knotweed Extract tablets
  • Japanese Knotweed Extract capsules
  • Japanese Knotweed liquid extract

Glentworth Formulations is here to suit your every need. Everything from Tablets, Capsules and Powder blends.

If you are wanting to know more information, please get in contact with us. Either using the contact form or contacting us directly on:

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