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Bitter orange extract is extracted from the fruit of the bitter orange plant, Citrus aurantium. This fruit is often found in subtropical regions and is oval or oblong in shape. When fully ripe, the fruit turns red-orange and is distinguished by its thick, dimpled skin. The fruit, as the name implies, has an exceedingly bitter taste. There are various bitter orange cultivars, with the Bergamot variation being one of the most well-known. The level of bitterness varies between cultivars. It has a variety of powerful plant components, some of which are isolated from the dried peel for use in dietary supplements.

One such compound is p-synephrine, a proprietary extract included in herbal weight loss supplements such as Advantra Z and Kinetiq. This extract is available in capsules, essential oils, powdered or liquid supplements, and other forms.

a photo depicting half sliced oranges: bitter orange extract


Bitter orange extract, which is derived from the Citrus aurantium tree, has a number of possible health benefits, making it an important component of both traditional and alternative medicine. This citrus fruit extract has been studied for therapeutic purposes and is well-known for its numerous health-promoting characteristics. Here are a few of its benefits:

  • Treat fungal infections: One of the most notable health benefits of this extract is its ability to treat fungal infections. When applied topically, this extract has been demonstrated to be incredibly effective in inhibiting fungal growth, with one research revealing a staggering 96.43% reduction. This extract can be used to treat common skin problems such as ringworm and athlete’s foot. Furthermore, when utilising this orange externally, there have been very few, if any, reported unfavourable side effects. This means it can be used as a natural treatment for fungal diseases with no or little risk.
  • Promotes skin health: This extract has significant skin health benefits, owing to its high vitamin C concentration. Vitamin C is an important precursor to collagen, helping to maintain skin integrity and aiding the body’s natural repair mechanisms. Fresh bitter orange has a high vitamin C concentration, with each serving providing 50 to 100% of the daily requirement. Individuals can assist ensure the health and brightness of their skin by integrating this orange into their daily plan.
  • Aid in weight loss: This extract also holds a lot of potential as a weight loss supplement, especially when paired with caffeine, according to a study. When used consistently over a 6- to 12-week period, its main ingredient, p-synephrine, serves as a stimulant and has been shown to enhance metabolic rate and energy expenditure. Because of these properties, this extract may be useful for people trying to lose weight. It is crucial to note, however, that the usage of supplements, particularly this extract, should be done with caution and, ideally, under the supervision of a healthcare practitioner. Individual reactions to these supplements may differ, necessitating safe and informed use.
weight management: Apple cider vinegar & Chromium & Carallum Fimbriata extract & cha de bugre & bitter orange extract

While bitter orange extract has a variety of health benefits, it is important to note that individual responses vary, and the use of any supplement should be done with caution and awareness. This extract shows promise in the domain of natural health and wellness, whether used to treat fungal infections, as a source of skin-enhancing vitamin C, or as a potential supporter of weight loss attempts. As with any dietary or pharmaceutical addition, discussing with a healthcare practitioner is a smart step to ensure safe and appropriate administration, allowing you to get the benefits of this citrus-derived extract.


When bitter orange extract is consumed, it interacts with the body via its active ingredient p-synephrine, which has actions similar to ephedrine, a stimulant that was widely used in weight reduction and energy supplements until being prohibited owing to health concerns. P-synephrine functions in the body by attaching to certain adrenergic receptors, primarily the beta-3 adrenergic receptors present in fat cells. P-synephrine increases lipolysis, which is the process of breaking down stored fat into free fatty acids for usage as energy, via attaching to these receptors. This can raise metabolic rate and calorie expenditure, perhaps leading to weight loss. P-synephrine may also aid to suppress appetites, making it easier for people to stick to a calorie-restricted diet.

 (salad bowl) calorie restricted diet: bitter orange extract

Furthermore, p-synephrine can have a modest stimulating impact via boosting norepinephrine release. Norepinephrine is a neurotransmitter that improves alertness, focus, and energy levels. This stimulant impact is often milder than that of caffeine, making this extract a viable choice for people who are sensitive to powerful stimulants. Furthermore, this extract may also aid in thermogenesis, or the generation of heat in the body. This mechanism can help with calorie burning and weight loss by elevating body temperature.

While bitter orange extract has showed promise in aiding weight loss, it should be used with caution and under the supervision of a healthcare practitioner, especially for people who have underlying health concerns or are taking other medications.


The dosage of bitter orange extract recommended varies based on the compound present and the intended usage. Doses of 50-98 mg per day are deemed safe for most people when taking p-synephrine supplements. A study found that combining 40 mg of synephrine and 320 mg of caffeine is safe when both compounds are used together. Furthermore, studies on the eating of a full bitter orange, which naturally contains roughly 30.6 mg of p-synephrine, found no pharmaceutical interactions.

While these dosages are usually regarded safe, some groups, such as pregnant or breastfeeding women, should avoid using bitter orange extract due to inadequate safety evidence in these groups. When considering the usage of bitter orange supplements, it is critical to contact with a healthcare practitioner because individual reactions to the extract vary and some people may be more sensitive to its effects.


Bitter Orange Extract is also available as:

  • Citrus Aurantium (Bitter Orange) Extract 10% Synephrine (Citrus aurantium l.)
  • Citrus Aurantium (Bitter Orange) Extract 30% Hesperidin (Citrus aurantium)
  • Citrus Aurantium (Bitter Orange) Extract 35% Bioflavonoids (Citrus aurantium l.)
  • Citrus Aurantium (Bitter Orange) Extract 35% Bioflavonoids 5:1 (Citrus aurantium l.)
  • Citrus Aurantium (Bitter Orange) Extract 35% Hesperidin (Citrus aurantium l.)
  • Citrus Aurantium (Bitter Orange) Extract 40% Hesperidin (Citrus aurantium l.)
  • Citrus Aurantium (Bitter Orange) Extract 45% Flavonoids 2% Synephrine (Citrus aurantium l.)
  • Citrus Aurantium Extract 50% Bioflavonoids (Citrus aurantium l.)
  • Citrus Aurantium Extract 6% Synephrine (Citrus aurantium l.)
  • Citrus Aurantium Extract 60% Bioflavonoids (Citrus aurantium l.)
  • Citrus Aurantium Extract 60% Bioflavonoids 35% Hesperidin 5:1 (Citrus aurantium l.)
  • Citrus Aurantium Extract 85% Hesperidin (Citrus aurantium)
  • Citrus Aurantium Extract 94% Hesperidin (Citrus aurantium)
  • Citrus Aurantium Extract 95% Bioflavonoids (Citrus aurantium l.)
  • Citrus Aurantium Extract 98% Hesperidin (Citrus aurantium)
  • Citrus Aurantium Whole Fruit Powder (Citrus aurantium l.)

Bitter Orange Extract is commonly available in:

  • Bitter Orange Extract capsules
  • Bitter Orange powder extract
  • Bitter Orange liquid extract

Glentworth Formulations is here to suit your every need. Everything from Tablets, Capsules and Powder blends.

If you are wanting to know more information, please get in contact with us. Either using the contact form or contacting us directly on: enquiries@glentworthformulations.com.

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