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Grapeskin extract is a natural nutritional supplement made from the skin of grapes, most often red or purple grape varietals. This extract is recognised for having a high concentration of bioactive compounds, notably polyphenols such as resveratrol, anthocyanins, and quercetin. These chemicals have been linked to a variety of possible health benefit, including antioxidant and anti-inflammatory activities, cardiovascular support, and protection against some chronic illnesses.

a photo of a grape tree, from which grape skin extract is derived

Grapeskin extract is frequently used as a supplement or added to food and drinks to capitalise on the health-promoting benefits of these grape-derived polyphenols. While research on the precise health benefits of grapeskin extract is underway, it is generally known for its potential as a natural source of powerful antioxidants and other bioactive elements that are beneficial to the body.


Here are some potential benefits of Grape Skin extract:

  • Boosts cardiovascular health: Grape skin extract, which is high in polyphenols, notably proanthocyanidins, plays an important function in cardiovascular health. These polyphenols are powerful antioxidants that assist to combat oxidative stress and inflammation, both of which play important roles in the development of heart disease. Blood vessel damage can be caused by oxidative stress, and inflammation can contribute to the development of atherosclerotic plaques. Grape skin extract’s anti-inflammatory and antioxidant properties are thought to help lessen these hazards, according to studies. Furthermore, proanthocyanidins have been linked to improved blood vessel function and circulation, which may reduce the risk of hypertension and atherosclerosis. These combined properties make grape skin extract a controversial topic in the world of heart health.
    benefits of grape skin extract: improves cardiovascular health
  • Wound Healing: One of the most notable aspects of grape skin extract’s health benefits is its exceptional ability to heal wounds. When proanthocyanidin extract from grape skin is given topically to wounds in mice, it speeds up the healing process. While the precise processes underlying this acceleration are unknown, grape skin extract has been shown to stimulate the synthesis of vascular endothelial growth factor (VEGF). VEGF is a molecule that stimulates the formation of new blood vessels during the wound healing process. This suggests that grape skin extract may have promise for cutaneous wound healing and may have uses in a variety of therapeutic situations.
  • May improve bone health: Grape skin extract has been shown to improve bone health when paired with calcium. In a research on mice fed a low-calcium diet, the addition of grape seed extract alongside calcium showed favourable benefits on bone growth and strength. This is especially important for those who have low calcium levels because the extract’s components, notably proanthocyanidins, appear to improve bone structure. The combination of grape skin extract and calcium may be an useful dietary component for persons wishing to build their bones, perhaps preventing bone-weakening disorders.

To summarise, despite encouraging research revealing possible health benefits of grape skin extract, it is critical to recognise that more extensive studies are required to determine the full breadth of its efficacy and safety in diverse applications. While it has the potential to help with cardiovascular health, wound healing, and bone strength, these findings are based mostly on animal studies, and their direct application to human health requires additional research.


When grape skin extract is consumed, it is absorbed in the gastrointestinal tract, particularly in the stomach and small intestine. Proanthocyanidins, resveratrol, and quercetin are among the beneficial substances released into the circulation and dispersed throughout the body. These antioxidant-rich chemicals serve to neutralise damaging free radicals and minimise oxidative stress, so preserving cells and tissues from damage. Furthermore, the anti-inflammatory actions of grape skin extract modify inflammatory pathways, potentially lowering chronic inflammation, which is connected to a variety of chronic illnesses, notably heart disease.It may help decrease blood pressure and reduce the risk of cardiovascular problems by improving blood vessel function and increasing blood flow.

blood flow enhancement: dong quai & cordyceps mushroom & grape skin extract

While these pathways provide insight into how grape skin extract may operate in the body, it is crucial to note that further research is being conducted to better understand the precise cellular and molecular interactions. While the potential health benefits are encouraging, further study is needed to fully understand the breadth of the effects of grape skin extract and its uses in human health. When contemplating grape skin extract as part of one’s health routine, it’s best to talk to a doctor, especially if you have any specific health issues or prescriptions.


The optimal dose of grape seed extract can be difficult to determine since it relies on a variety of factors, including an individual’s unique health goals, age, and the type of the extract utilised. Grape seed extract comes in a variety of forms, including capsules, tablets, and liquid extracts, each with a distinct concentration of active components. Although research and clinical studies have looked at a variety of amounts, the recommended daily consumption is still being debated.

Numerous studies have employed grape seed extract concentrations ranging from 100 to 300 milligrams per day to investigate its possible health benefits, such as antioxidant and cardiovascular effects. However, keep in mind that individual reactions may vary, and the appropriate dose may alter depending on a person’s specific health needs. Furthermore, because the concentration of active substances varies between brands and formulations, it is best to choose a reputed product with standardised content to guarantee constant and correct dosing.

As research in this field develops, healthcare experts will be able to provide the most up to date advise on doses that fit with particular health goals, assisting patients in making educated decisions regarding the use of grape seed extract as a dietary supplement.


Grape Skin Extract is also available as:

  • Grapeskin Extract 35% Polyphenols (Vitis vinifera)
  • Grapeskin Extract 4:1
  • Grapeskin Extract 8:1 (Vitis vinifera)
  • Grapeskin Extract Soluble 10% Polyphenols (Vitis vinifera)

Grape Skin Extract is commonly available in:

  • Grape Skin Extract capsules
  • Grape Skin powder extract
  • Grape Skin liquid extract

Glentworth Formulations is here to suit your every need. Everything from Tablets, Capsules and Powder blends.

If you are wanting to know more information, please get in contact with us. Either using the contact form or contacting us directly on:

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